Losing weight can be challenging, especially for individuals struggling with conditions like diabetes and polycystic ovary syndrome (PCOS). Fortunately, there is a medication that has been shown to help with weight loss in these individuals: Metformin. Metformin is a commonly prescribed medication for managing diabetes but has also been found to have weight loss benefits.
In recent years, there has been increasing interest in using Metformin for weight loss, especially for individuals with diabetes or PCOS.
So if you want to lose weight with Metformin, this blog is for you.
This blog post will explore the science behind Metformin and its weight loss benefits. We will also discuss how Metformin works, the potential side effects, and how to determine if this medication is right for you.
Is Metformin Pill Effective for Losing Weight Loss?
You’re not going to lose a lot of weight. In the diabetes prevention trial, 29% of participants dropped 5% more than their body weight, while only 8% lost 10% or more. That was approximately 5 pounds on average.
It may be sufficient to begin improving your health, but it will not significantly influence if you are overweight. Metformin, for example, will not create a change for someone who has to reduce 30 pounds or more.
In that study, a group of individuals changed their diet and exercise habits rather than taking the pills.
So, you can Lose weight with Metformin by taking the medication as prescribed by your healthcare provider and combining it with a healthy diet and regular exercise.
Therefore, Metformin’s long-term weight loss rate of success is similar to that of lifestyle changes, which have other benefits such as improving your health.
How Metformin Can Help You Lose Weight?
The FDA does not approve Metformin as a stand-alone weight-loss medication.
On the other hand, those who use Metformin for other purposes may experience weight loss as a side effect. The specific mechanism is unknown. Unlike other diabetic treatments, Metformin does not promote weight gain.
Reduced appetite –
The theory is that Metformin causes people to eat less by suppressing their appetite. Yet, the mechanisms through which Metformin impacts hunger are unclear.
Metformin may disrupt the gut flora, trigger the production of appetite-suppressing hormones, and influence appetite-regulating areas of the brain.
Some metformin users may also develop diarrhea, bloating, and nausea. Some adverse effects may make a person want to eat less.
Long-term weight loss –
Long research on diabetics tracked weight loss over 15 years. Researchers discovered that individuals who dropped more than 5% of their body weight within the first year had a better chance of maintaining their weight loss in 6 to 15 years.
On the other hand, using the medicine without other healthy practices may not result in weight loss. People who exercise and eat a healthy diet while using Metformin are those who lose more weight.
Also, any losing weight experience could only last as you continue to take the drug. It means that if users stop taking Metformin, you’re likely to regain their previous weight. Also, while taking medicine, people may gradually regain their lost weight.
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How Does Metformin Work?
Metformin begins to operate in the intestine. Some experts believe it alters the natural bacteria balance in the digestive tract. It also activates particular enzymes that aid the body’s utilization of fat.
Scientists are also attempting to figure out how Metformin causes weight reduction. Digestive difficulties are typical adverse effects since it affects gut flora.
Thus one early notion was that stomach pain led individuals to lose their appetite and consume less or that diarrhea caused them to lose water weight. However, the majority of these adverse effects subside after a few weeks. Those who dropped weight on Metformin kept losing weight after that.
A more reasonable reason is that Metformin’s effects on the intestines suppress hunger. It may increase the amount of the hormone leptin in the body, which makes you feel full. You eat less because hunger isn’t working overtime.
The weight people lose on the medicine is largely from fat storage rather than the combination of body fat and lean muscle that occurs with dieting. Metformin users also had reduced waist size and waist-to-hip ratios, measures of body fat.
What is the average weight loss with Metformin?
The connection between Metformin and weight is unclear; however, weight changes can be explained by various factors.
In one research, 12 women with type 2 diabetes and obesity who did not use insulin were randomly assigned to receive one of two metformin doses — 850 milligrams (mg). Participants completed a meal test every third day and evaluated their hunger levels before eating. Researchers discovered that hunger levels were considerably lower in the metformin group.
Another research published in the journal Diabetes Care in May 2020, discovered that when individuals raised their metformin dosage by 1,000 mg or more, they shed considerably more weight compared to those who did not modify or decrease their dose.
What is the recommended dosage for weight loss?
Metformin is a diabetic treatment. As a treatment for weight loss, there are no established dosing guidelines.
If your doctor prescribes Metformin off-label, they will determine the best dose based on your medical history. Metformin will likely be started at a low dose and progressively increased over a few weeks. This can assist in reducing any negative effects.
Metformin has an off-label usage for antipsychotic drug-induced weight reduction. The dosage for instant Metformin can vary from 750 mg to 2,000 mg.
Also Read: Diabetes Diet Plan: Foods to Eat and Avoid
What else can result in weight loss?
If you’re losing weight while using Metformin, it might be due to the medicine. Several things might also cause weight loss.
Digestive problems –
Digestive system problems can also cause weight loss. Here are some of the issues:
- Irritable bowel syndrome.
- Infection in the stomach or intestine.
- Surgery on the stomach or intestines.
- Additional medical problems.
Certain health issues can induce appetite loss, contributing to weight loss. Here are some of the conditions:
- Chronic obstructive pulmonary disease
- Parkinson’s disease (neurological disorder)
Other drugs may also cause weight loss. Chemotherapy medicines, for example, may accomplish this by suppressing your appetite.
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Metformin can lead to modest weight loss in some individuals with and without diabetes. Despite this, experts are currently investigating why the medication has this impact. Several factors, including appetite suppression caused by the drug’s negative effects, are probably in effect.
Finally, there are other solutions other than Metformin. The most significant fact you may do to weight loss, whether for type 2 diabetes management or other reasons, is to adjust your diet and lifestyle. Consider Metformin to be a complement to those steps.
However, remember that Metformin is now only allowed for specific people with type 2 diabetes, not really for those who do not have the disease. If you’re taking the medication to lower your blood sugar,
If you’re using Metformin to lower your blood sugar in the event of diabetes, remember that the medication has adverse effects that you should discuss and manage with the healthcare provider.