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Why does gluconeogenesis occur in the liver?
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Gluconeogenesis is a metabolic process that results in the generation of glucose from non-carbohydrate carbon substrates like lactate, glycerol, and glycogenic amino acids. Liver cells or hepatocytes have glucagon receptors. Glucagon can easily target the liver. When glucagon binds to the glucagon receptors it is then converted into individual glucose molecules by liver cell and release them into the bloodstream, this process is known as glycogenolysis. Glycogenolysis takes place in the cells of liver tissues in response to hormonal and neural signals. In general, glycogenolysis plays an important role in the fight-or-flight response of liver and the regulation of glucose levels in the bloodstream.