2
Why does the liver enlarge in thalassemia?
- 1 people answered
3 Votes
1 Contributor
3346 Views 
0 Saved
3 Votes 1 Contributor3346 Views 0 SavedYou might also be interested in
The liver plays an important role in the digestion. The reason for this is that when digested nutrients from the small intestine drain directly into veins which connect into the portal vein. Therefore these nutrients need to be filtered as a first stop before going to the rest of the organs. Blood f....
Caffeine has multiple short- and long-term effects on the body, including effects on the liver. Caffeine affects the blood sugar function of the liver which helps prevent diabetes or diabetes symptoms. Despite this potential caffeine should not be used medically to treat or prevent any condition unl....
The liver is involved in metabolizing many toxins, including drugs and medications, chemicals, and natural substances. Liver disease causes the liver to function abnormally, as a result enhancing formation of toxins which results in inflammation. This further erodes stomach lining forming sores in t....
Akanksha Pardeshi
The enlargement of Liver happens due to continuous transfusions without adequate chelation.
If there is no chelation at all it will enlarge quickly and vice versa. So, Hepatomegaly does happen in Thalassemia because Liver stores the excess iron which remains in the body due to inadequate chelation. Is the case of thalassemia, organs are expanding due to the dual effects of low hemoglobin in the body. In some cases, the bone marrow can produce some amount of misshaped RBCs.
The Spleen then becomes hyperactive to get rid of these cells, which in turn leads to the bone marrow trying to work some more - in effect, a vicious cycle develops where the spleen will get enlarged and the bone marrow will expand, weakening the bones. The only key to Success over Thalassemia is Adequate Transfusion with Adequate Chelation without worrying about future.