2
Why does the liver enlarge in thalassemia?
- 1 people answered
3 Votes
1 Contributor
3361 Views 
0 Saved
3 Votes 1 Contributor3361 Views 0 SavedYou might also be interested in
The main plasma lipid transport forms are triglyceride, free fatty acid and cholesteryl ester. Triglycerides are used in the making of some hormones and enzymes the body needs. It is also used in the manufacture of cell membranes in our bodies. Even if we limited our consumption of them, the liver w....
Tramadol is harmful when taken in large doses but it can be harmful even in normal doses if you have an unhealthy liver. Tramadol is a medication used for the therapy of mild-to-moderate pain. Tramadol overdose can result in acute liver failure. If you have liver diseases or a history of liver disea....
The portal vein is responsible for transports cholesterol in chylomicrons from the intestine to the liver. Chylomicrons are tiny balls that enclose fatty particles like cholesterol. The hepatic portal vein is one of the most important veins that helps in receiving blood from the body and transports ....
Akanksha Pardeshi
The enlargement of Liver happens due to continuous transfusions without adequate chelation.
If there is no chelation at all it will enlarge quickly and vice versa. So, Hepatomegaly does happen in Thalassemia because Liver stores the excess iron which remains in the body due to inadequate chelation. Is the case of thalassemia, organs are expanding due to the dual effects of low hemoglobin in the body. In some cases, the bone marrow can produce some amount of misshaped RBCs.
The Spleen then becomes hyperactive to get rid of these cells, which in turn leads to the bone marrow trying to work some more - in effect, a vicious cycle develops where the spleen will get enlarged and the bone marrow will expand, weakening the bones. The only key to Success over Thalassemia is Adequate Transfusion with Adequate Chelation without worrying about future.