2
Why does the liver enlarge in thalassemia?
- 1 people answered
3 Votes
1 Contributor
3224 Views 
0 Saved
3 Votes 1 Contributor3224 Views 0 SavedYou might also be interested in
Following are the causes of dehydration: Fever Peeing a lot (esp in case of Diabetes) Excessive sweating Diarrhoea - The body excretes too much water, leading to dehydration. Vomiting - This leads to a loss of fluids & makes it hard to replace water while drinking it. Followin....
Dr Thomas Starzl was the first surgeon who transplanted liver. He died at the age of 90years. The first attempt was performed in 1963 but the patient died due to uncontrolled bleeding. Until 1967 multiple unsuccessful attempts were made by various surgeons. In 1967 Dr Thomas transplanted liver of ni....
Gluconeogenesis is a metabolic process that results in the generation of glucose from non-carbohydrate carbon substrates like lactate, glycerol, and glycogenic amino acids. Liver cells or hepatocytes have glucagon receptors. Gluconeogenesis occurs in the kidneys and only in the liver. This is due to....
Akanksha Pardeshi
The enlargement of Liver happens due to continuous transfusions without adequate chelation.
If there is no chelation at all it will enlarge quickly and vice versa. So, Hepatomegaly does happen in Thalassemia because Liver stores the excess iron which remains in the body due to inadequate chelation. Is the case of thalassemia, organs are expanding due to the dual effects of low hemoglobin in the body. In some cases, the bone marrow can produce some amount of misshaped RBCs.
The Spleen then becomes hyperactive to get rid of these cells, which in turn leads to the bone marrow trying to work some more - in effect, a vicious cycle develops where the spleen will get enlarged and the bone marrow will expand, weakening the bones. The only key to Success over Thalassemia is Adequate Transfusion with Adequate Chelation without worrying about future.