Does Ozempic Need to Be Refrigerated? Storage Rules You Must Know

Whether you are starting Ozempic (semaglutide) for the first time or have been using it for a while, one question often comes up: Does Ozempic need to be refrigerated? The way you store this medication isn’t just a small detail; it directly affects how well it works and, ultimately, your diabetes management.

Improper storage can reduce its potency, making treatment less effective. That’s why it’s important to know exactly when Ozempic must stay refrigerated and what to do once you’ve opened it. In this article, we’ll clear up the confusion and guide you step by step on how to keep your medication safe and effective throughout its use.

Does Ozempic Need to be Refrigerated?

Yes, you need to refrigerate Ozempic, especially an unopened one. If you are using Ozempic (an injectable pen) for managing type 2 diabetes or sometimes for weight loss, knowing the proper storage tips is crucial to maintain the effectiveness of the medicine and avoid the risk of side effects:

Here are the storage guidelines:

Before First Use

To maintain the stability and strength of the Ozempic pen:

• Store it in the refrigerator between 36°F and 46°F, (2°C and 8°C).

• Keep it in the original box to protect it from sunlight.

• Do not freeze it. If frozen, discard it.

• Store it until its expiry date only when refrigerated properly.

After First Use

To ease maneuverability (the ability of the medication to move precisely and efficiently) after opening, you have 2 storage options:

• Keep it in the refrigerator between 36°F and 46°F.

• Store it at room temperature (59°F to 86°F or 15°C to 30°C) for about 56 days.

Important Tips:

• Avoid exposure of the Ozempic pen to direct sunlight or heat.

• After opening, use the pen for up to 56 days. Discard it after this period, even if some amount is left in the pen. 

• Do not leave the pen near windows, in a car, or in places where the temperature can increase or drop.

• Always make sure the solution in the pen is clear and colorless. If it turns cloudy or has particles, avoid using it.

Why Refrigeration Matters?

Ozempic consists of the active ingredient called semaglutide, which is a protein that is prone to changes in temperature. Heat can break its molecular structure, reducing the effectiveness of the medication or making it potentially harmful. Hence, proper refrigeration before and after use is crucial.

Here is the importance of proper storage:

• Improves effectiveness in controlling blood sugar levels.

• Avoids protein degradation that may lead to side effects like nausea, vomiting, and abdominal pain.

• Prevents the growth of bacteria in compromised solutions.

• Eliminates the risk of crystallization that prevents blocking of the injection mechanism.

How Long Can Ozempic Stay Unrefrigerated?

Here is what you should keep in mind:

• Once opened, you can keep the pen out at room temperature at 59ºF to 86ºF or 15ºC to 30ºC.

• Use it within 56 days once it is removed from cold storage, as a 2023 study says that injectable Ozempic remains stable for 56 days after first use. 

• Discard it after 56 days, even if there is some amount left.

• Unopened pens remain usable until the expiration date printed on the label, as long as they are kept refrigerated.

What Happens if Ozempic is Not Refrigerated Before First Use?

If left unrefrigerated before the first use, the heat can break down semaglutide molecules, reducing the potency of the medicine to control blood sugar levels or lose weight. Moreover, it makes the solution cloudy or develop particles, and causes bacterial growth, further impacting the effectiveness. This, in turn, can lead to:

• Blood sugar spikes

• Injection site reactions, like extreme pain, swelling, or redness

• Inconsistent results

• Issues with the pen mechanism due to crystallization

If the Ozempic is left unrefrigerated, discard it. Remember that if not refrigerated after the first use, you can still use it. Visit the pharmacies to get a new pen. Moreover, if not sure about the use of a pen, contact pharmacies or reach the manufacturer by calling 800-727-6500.

Can You Freeze Ozempic?

No, do not freeze Ozempic, so avoid storing it below 35°F. Freezing can cause the solution to undergo physical and chemical changes, impacting its effectiveness. Even leaving the solution to melt can't fix it. The best advice is to avoid using it. Get the new pen to receive the complete benefit of Ozempic. 

Ozempic Room Temperature Stability: What You Need to Know

56-Day Window: After it is opened, Ozempic can be kept at room temperature up to 86°F or 30°C for no more than 56 days.

Temperature Sensitivity: Extreme temperatures affect Ozempic. It should not be stored in places where the temperatures go beyond 86°F since this might cause it to lose its potency.

Avoid Direct Sunlight: Exposing Ozempic to direct sunlight is not recommended, as this may reduce its efficacy.

Do Not Freeze: It is strictly forbidden to freeze Ozempic because doing so will destroy the drug, making it useless.

Original Packaging: To protect it from light, keep Ozempic in its original package until you are ready to use it.

What Happens if You Use Expired Ozempic? Using Ozempic after its expiry date or for more than 56 days at room temperature can decrease its effectiveness and is not advisable.

Safety while Transporting: During travel, carry-on luggage should be used when carrying ozepmic to prevent exposure to extreme temperatures such as those found in checked baggage compartments.

Traveling with Ozempic: Here's the Storage Tips

Short Trips (Under 56 Days)

• Use an insulated medical travel bag or cooler bag with ice packs while traveling, especially to warm places.

• Allow the pen to reach room temperature for about 30 minutes before injecting it.

• Never keep in direct sunlight or in hot cars.

Long Trips (More than 56 Days)

• Purchase a cooling case or a medication refrigerator to carry the pens.

• Research the locations of the pharmacies at your destination to get your pen refill.

• Carry the prescription note given by your doctor for airport security.

Important Tips:

• Place it inside a carry-on luggage bag when traveling by train or air to avoid subjecting it to extreme conditions found within checked baggage compartments.

• When traveling by car, keep the pens in the main body of your car instead of the trunk for proper control of temperature.

• As soon as you reach your destination, please ensure you have access to a fridge to keep your Ozempic. If not available, ask the hotel staff to safely store your medicine.

• If your medicine gets hot due to exposure to high temperatures, talk with a local pharmacist or call your doctor for advice before using the medication.

Storage Do's & Don'ts

DO's:

• Store the pen in the main compartment of the refrigerator (not in the door).

• Avoid placing it in the freezer compartment.

• Allow the pen to sit at room temperature before using it to reduce the risk of discomfort.

DON'Ts:

• Storing the pen in extreme temperatures (under 32°F or over 86°F after the first use).

• Storing it near the heat sources or in direct sunlight.

• Shaking the pen harshly.

Possible Signs of Compromised Ozempic

Look for the signs that indicate your Ozempic may not be effective:

• Cloudy or discolored (as it should appear clear and colorless)

• Visible particles moving in the solution

• Crystallization (formation of solid crystals) around the area of the needle

• Pen mechanism not functioning effortlessly or smoothly

• Strange reactions after injecting the pen

Note: If these signs sound familiar, avoid using the medicine and seek medical help. 

Ozempic Shelf Life: Unopened Vs. Opened

Here's a detailed look at Ozempic shelf life, both unopened and after it's been opened:

Ozempic shelf life unopened: Ozempic should be kept refrigerated until the first use, which preserves its quality up to the printed expiration date.

How long is Ozempic good for once opened? Once you start using an Ozempic pen, it can either be stored in the refrigerator or at room temperature, but it should be used within 56 days to ensure it remains effective.

Final Thoughts

Does Ozempic need to be refrigerated? Yes, refrigeration is essential before first use to maintain its effectiveness and safety. Once opened, Ozempic can be kept at room temperature for up to 56 days, but always track storage times carefully. Proper handling ensures it works as intended for managing diabetes or supporting weight loss. If you have any concerns, consult your healthcare provider for personalized advice.

Discover more Ozempic-related reads: Ozempic Vs Saxenda: Which One is Best for Weight Loss? | Ozempic Face: What You Need to Know | Ozempic Nausea Relief: How To Feel Better